COVID-19 is an emerging, rapidly evolving situation. https://m.vk.com/wall412311521_672 Get the latest public health information from CDC: https://www.coronavirus.gov . Get the latest research from NIH: https://www.nih.gov/coronavirus. Skip to main page content National Institutes of HealthU.S. National Library of MedicineNCBI homepageLog in Access keysNCBI HomepageMyNCBI HomepageMain ContentMain Navigation Advanced Full-text links Review The Origin, Transmission and Clinical Therapies on Coronavirus Disease 2019 (COVID-19) Outbreak - An Update on the Status Yan-Rong Guo et al. Mil Med Res. 2020 Show details Full-text links Cite Abstract An acute respiratory disease, caused by a novel coronavirus (SARS-CoV-2, previously known as 2019-nCoV), the coronavirus disease 2019 (COVID-19) has spread throughout China and received worldwide attention. On 30 January 2020, World Health Organization (WHO) officially declared the COVID-19 epidemic as a public health emergency of international concern. The emergence of SARS-CoV-2, since the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, marked the third introduction of a highly pathogenic and large-scale epidemic coronavirus into the human population in the twenty-first century. As of 1 March 2020, a total of 87,137 confirmed cases globally, 79,968 confirmed in China and 7169 outside of China, with 2977 deaths (3.4%) had been reported by WHO. Meanwhile, several independent research groups have identified that SARS-CoV-2 belongs to β-coronavirus, with highly identical genome to bat coronavirus, pointing to bat as the natural host. The novel coronavirus uses the same receptor, angiotensin-converting enzyme 2 (ACE2) as that for SARS-CoV, and mainly spreads through the respiratory tract. Importantly, increasingly evidence showed sustained human-to-human transmission, along with many exported cases across the globe. The clinical symptoms of COVID-19 patients include fever, cough, fatigue and a small population of patients appeared gastrointestinal infection symptoms. The elderly and people with underlying diseases are susceptible to infection and prone to serious outcomes, which may be associated with acute respiratory distress syndrome (ARDS) and cytokine storm. Currently, there are few specific antiviral strategies, but several potent candidates of antivirals and repurposed drugs are under urgent investigation. In this review, we summarized the latest research progress of the epidemiology, pathogenesis, and clinical characteristics of COVID-19, and discussed the current treatment and scientific advancements to combat the epidemic novel coronavirus. Keywords: Clinical characteristics; Coronavirus disease 2019 (COVID-19); Origin; SARS-CoV-2; Therapy; Transmission. Conflict of interest statement The funder had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript. The authors declare that they have no competing interests. Figures Fig. 1 Fig. 1 13 Viral and host factors that influence the pathogenesis of SARS-CoV-2. Bats are the... Similar articles Three Emerging Coronaviruses in Two Decades. Guarner J. Am J Clin Pathol. 2020. PMID: 32053148 No abstract available. A Review of Coronavirus Disease-2019 (COVID-19). Singhal T. Indian J Pediatr. 2020. PMID: 32166607 Review. Novel coronavirus 2019-nCoV: prevalence, biological and clinical characteristics comparison with SARS-CoV and MERS-CoV. Meo SA, et al. Eur Rev Med Pharmacol Sci. 2020. PMID: 32141570 Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lu R, et al. Lancet. 2020. PMID: 32007145 COVID-19 (Novel Coronavirus 2019) - recent trends. Kannan S, et al. Eur Rev Med Pharmacol Sci. 2020. PMID: 32141569 Review. Show more similar articles See all similar articles References Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020;395(10224):565–574. doi: 10.1016/S0140-6736(20)30251-8. - DOI - PubMed WHO . Coronavirus disease (COVID-2019) situation reports. 2020. Riou J, Althaus CL. Pattern of early human-to-human transmission of Wuhan 2019 novel coronavirus (2019-nCoV), December 2019 to January 2020. Euro Surveill. 2020;25(4):2000058. doi: 10.2807/1560-7917.ES.2020.25.4.2000058. - DOI - PMC - PubMed Liu Y, Gayle AA, Wilder-Smith A, Rocklov J. The reproductive number of COVID-19 is higher compared to SARS coronavirus. J Travel Med. 2020. 10.1093/jtm/taaa021. - PMC - PubMed Chan JF, Yuan S, Kok KH, To KK. Chu H, Yang J, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020;395(10223):514–523. doi: 10.1016/S0140-6736(20)30154-9. - DOI - PubMed Show all 105 references Publication types Research Support, Non-U.S. Gov't Review MeSH terms Adult Aged Alphacoronavirus / genetics Animals Betacoronavirus / genetics Betacoronavirus / pathogenicity China / epidemiology Chiroptera Coronavirus Infections / diagnosis Coronavirus Infections / epidemiology Coronavirus Infections / therapy Coronavirus Infections / transmission Cough / etiology Diarrhea / etiology Disease Outbreaks * Disease Reservoirs Fatigue / etiology Female Fever / etiology Humans Male Middle Aged Middle East Respiratory Syndrome Coronavirus / genetics Middle East Respiratory Syndrome Coronavirus / pathogenicity Peptidyl-Dipeptidase A Pneumonia, Viral / diagnosis Pneumonia, Viral / epidemiology Pneumonia, Viral / therapy Pneumonia, Viral / transmission SARS Virus / genetics SARS Virus / pathogenicity Viral Envelope Proteins Virulence Virus Replication Substances COVID-19 Viral Envelope Proteins Peptidyl-Dipeptidase A angiotensin converting enzyme 2 severe acute respiratory syndrome coronavirus 2 LinkOut - more resources Full Text Sources BioMed Central Europe PubMed Central PubMed Central Medical MedlinePlus Health Information Miscellaneous NCI CPTAC Assay Portal Source : https://pubmed.ncbi.nlm.nih.gov/32169119/

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